Brain Fog

2023 Review - Do Brain Fog Supplements Work?

What is Brain Fog?

You may have heard a lot of people lately using the term “Brain fog”. This isn’t a medical condition. It’s a common term used for  symptoms that can affect:

  • memory problems

  • a lack of mental clarity

  • poor concentration

  • an inability to focus

It is also described as mental fatigue. If brain fog and fatigue are causing significant issues, you should always consult with a doctor! But you may be able to troubleshoot the symptoms and find some relief. Let's look at the causes of brain fog, and is there a brain fog cure? What helps brain fog?

Brain Fog Supplement

What causes Brain Fog and Fatigue?


In 2017, researchers found that chronic stress has a negative effect on health. Stress increases blood pressure, weakens the immune system, damages the gut, and triggers depression. It also causes mental fatigue and ‘brain fog feeling’.

Sleep Quality

Poor sleep quality can interfere with how well your brain functions. Read the 2021 research here.

Stress can also affect your sleep patterns. Keep stress in check to help you get 8 to 9 hours of sleep per night.

Hormonal changes

Hormonal changes can also trigger brain fog, according to research completed in 2018.

Levels of the hormones progesterone and estrogen increase during pregnancy. This change can affect memory and cause a short-term lack of focus.

A drop in estrogen levels during menopause can cause forgetfulness and poor concentration, according to researchers in 2019.

Diet and Hydration

Diet can also play a role in brain fog. Sugary or heavy meals can lead to an energy crash, leaving you feeling tired and foggy.  Some nutrient deficiencies can also play a part.  For example, Vitamin B12 supports healthy brain function. A vitamin B12 deficiency can lead to brain fog, according to a 2021 research review.

All the cells in the body (including brain cells) depend on water to carry out essential functions. So in dehydration, our brain cells cannot function properly, leading to cognitive problems.

A dehydrated brain show increased neuronal activation when performing cognitively engaging tasks. This indicates that their brains are working harder than normal to complete the task according to research in 2018.


Researchers in 2021 found that some medications can affect cognitive function. If you notice brain fog while taking medication, talk with your doctor.

Medical Conditions

Medical conditions associated with inflammation, fatigue, or changes in blood glucose level can affect cognitive function. Brain fog is a symptom of chronic fatigue syndrome, according to 2020 research.

Other conditions that may cause brain fog include:

  • anemia

  • depression

  • diabetes

  • migraine

  • Alzheimer’s disease

  • hypothyroidism

  • autoimmune diseases

  • viral infections, like COVID-19

Supplement for Focus and Energy

Is there a Supplement for Focus and Energy?

If you’ve tried everything else, you could consider ‘brain fog vitamins’. Brain fog supplements generally include natural ingredients. Adaptogenic mushrooms, adaptogens, and vitamins and minerals such as Zinc. They support cognitive function and energy, and have extra benefits for well-being.

Benefits of Brain Fog Supplements

There are many adaptogenic mushrooms and adaptogens that may help with brain fog. We are going to focus on 2 of Powderful’s ingredients - Lion’s Mane and Zinc. They are 2 of the most popular ingredients in brain fog supplements, and here is the research to explain why.

Support Memory & Concentration

-Lion’s mane is a popular brain fog supplement that supports cognitive function. Some studies show promising results using Lion’s Mane to reduce the symptoms of dementia but studies are ongoing. It is also a supplement for focus and energy.

-Zinc supplementation can also help with focus. Some studies have shown that people who have ADHD tend to have lower zinc levels.

Boost Natural Energy

There are a few reasons why lion’s mane may help to boost natural energy. First, lion’s mane contains antioxidants that support cellular health. Energy transport takes place between your cells, so the more antioxidants you have, the easier it is for your body to produce energy.

Lion’s mane has also been shown to reduce lactic acid in the blood, which may cause fatigue. It also promotes increased tissue glycogen content which promotes energy production.


2015 Research shows that lion’s mane mushrooms contain powerful anti-inflammatory and antioxidant compounds that may help reduce the impact of inflammation.

Mood and Stress

A recent study showed that Lion’s Mane reduced symptoms of stress and anxiety within 4 weeks of use. Participants ate cookies containing lion’s mane. Compared to a placebo group, they showed a significant reduction in stress, anxiety, and depression.

Looking for the best supplement for brain fog, a supplement for focus and energy, to boost natural energy or something to support your overall wellbeing? Powderful contains 15 natural ingredients with adaptogenic properties that could be a good place to start. Check out our ingredients page to find out more.

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